LabPad INR Point of Care System Utilising Lenseless Technology The Next Generation

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LabPad INR Point of Care System Utilising Lenseless Technology The Next Generation
LabPad®’s versatility comes especially from its Tsmart® single-use microcuvette, which contains a lyophilized reagent specific to each test.

The Tsmart® microcuvette is the fruit of numerous innovations that have led to many benefits for users, in particular:

1-ok-orangeFully automated "plug-and-play" behavior

2-bleu-okReduced blood volume (only 3µL)

3-bleu-okA large space for blood drop-off

4-violet-okFills up quickly, using just capillarity

5-violet-okEasy handling, thanks to its 3D shape

6-bleu-okOptimized preservation in individual pouches, in boxes of 48 units

Ever since it was founded, Avalun has focused its efforts on developing LabPad®, a connected Handy Lab designed to address the needs for multiparametric near-patient testing.

Based on a unique and patented lensless optical technology, this smart system consists of a fully automated "miniaturized microscope" and a range of Tsmart® single-use microcuvettes integrating innovative microfluidics. Once inserted into the device, the Tsmart® faces a CMOS sensor and is lit by different light sources. When capillary blood dissolves the Tsmart®’s embedded reagent, test-specific biological phenomena are observed in real time, and a dedicated image-processing algorithm produces the result.

LabPad® is a generic platform enabling measurements with the same device in the fields of:

  • Hemostasis, in particular with the PT/INR test (by blood dynamics imaging);
  • Biochemistry, in particular for blood glucose (by colorimetry);
  • Immunohematology, in particular for direct blood typing (by particle agglutination imaging);
  • Cytology (by microscopic image reconstruction);
  • Immunology, for measuring different biomarkers (by reading out immunochromatographic tests).

Building on these unique features, Avalun’s objective is to provide patients and healthcare professionals "here and now" with the reliable biological parameters they need. While developing LabPad®, special attention was paid to its functionalities and its ergonomics so that smooth integration into care processes can be obtained. Two U&A studies were carried out prior to and during the development phase. The first, which included 50 patients and 130 healthcare professionals, was conducted in 2013 by Pierre Mendès-France University (Grenoble, France); the second, more specifically dedicated to the environment of the "connected patient", was conducted by Sherbrooke University (Sherbrooke, Canada).

The first Tsmart® to be marketed makes it possible to measure coagulation time (PT/INR test). Additional tests are currently being designed, either by Avalun itself or by its partners. To accelerate the availability of new tests, Avalun intends to promote cooperation with in-vitro diagnostics players wishing to benefit from its technology.

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